I think Buffy (SMG) should come back to TV as a Watcher. As slayers generally all get killed in battle, it stands to reason that perhaps they get weaker as they age too. Buffy would still be powerful but nowhere near as powerful as she was as a teenager. Dealing with that would make for interesting drama. As the thankless irony unfolds further, the next generation of slayer would be even more self-absorbed that she was. Becoming a Watcher would make sense as the fight against evil continues to threaten the fabric of our reality. It could make for an excellent series. I would get out of Sunnydale too.
I would set the stage for the series with a vampire civil war. I'd make the vampires far more tribal in nature, meaning they're out to kill each other to establish dominance and power. The vampire civil war has made them far more desperate to make their numbers grow which makes Buffy's very reluctant and inevitable involvement in the war against evil even more vital to the survival of humanity. What would make things even more interesting is that Spike is the one who gets her to believe in the fight again.
Just my take.