Just wanted to give everyone that bought Prometheus a heads up! This occurred on my 2D version, so check your discs! I thought at first it was my player since I've been watching so many movies lately, but I'm glad it wasn't now.
My player didn't shut down, but the blocking was getting annoying so I stopped the movie. But after putting it back in and restarting, the blocking was gone when I watched the scene again. I'll still be exchanging it though.
From the DigitalBits:
"In other news today, a number of readers are reporting problems with Fox’s Prometheus Blu-ray. Throughout the second half of the film, some copies are plagued with macro-blocking and will occasionally cause players to simply shut down. It appears to be a manufacturing error and isn’t affecting all copies, so if you’re having trouble we recommend you exchange it with your retailer. You can also contact Fox Customer Care at 1-888-223-4369."