Yeah absolutely.
I buy everything im interested in digitally via comiXology. The individual issues i LOVE, i'll mail order bagged and boarded.. and the series I'm collecting I'll order the trade.
So, I'm following multiple comics digitally, but only "physically collecting" Batman books.
In many cases I find the colour to really pop more on an iPad than in print.
Additionally, I can carry VAST amounts of unread books with me on the iPad for planes, trains etc.. And, I can read and re-read without fear of wrecking a physical copy.
In terms of money, it's probably cheaper for me to buy digitally. New releases launch at $4.99 with a price drop to $1.99 after the next issue launches. Many comics are $0.99 or free.
Being based in a regional area in Australia - if (and that's a big if) I can find a physical copy locally it's going to be $8.99 for an individual issue.
I can order online and get one delivered, bagged and boarded for about $10. Or I can get trades via BookDepository or Amazon for cheaper - like $20 for Issues 1 - 7 or something.
So for me, I only get the physical ones that I truly love - as it's cheaper, more convenient and generally a better experience for me digitally.
(Plus I can indulge my collector-gene through getting everything digitally, without cluttering up my limited storage space of buying everything physically).
Lots of pro's to digital.
The con is the fact that you effectively "licence" the issue. If the provider, say ComiXology in this case, fails as a business in the future, I'll lose many of the comics I've purchased.
But so long as I have the ones I truly love bagged and boarded (and unread, so MIIIINT), then I'm okay with this. It's kinda like hiring a video for a couple of bucks, but then never having to return it unless the store chain goes belly up.
Frankly, I think ComiXology is likely to be around for a long time anyway.